GOChase-II: correcting semantic inconsistencies from Gene Ontology-based annotations for gene products.

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by Yu Rang Park, Jihun Ju Han Kim, Hye Won Lee, Young Jo Yoon
Abstract:
The Gene Ontology (GO) provides a controlled vocabulary for describing genes and gene products. In spite of the undoubted importance of GO, several drawbacks associated with GO and GO-based annotations have been introduced. We identified three types of semantic inconsistencies in GO-based annotations; semantically redundant, biological-domain inconsistent and taxonomy inconsistent annotations.
Reference:
GOChase-II: correcting semantic inconsistencies from Gene Ontology-based annotations for gene products. (Yu Rang Park, Jihun Ju Han Kim, Hye Won Lee, Young Jo Yoon), In BMC Bioinformatics, BioMed Central Ltd, volume 12 Suppl 1, 2011.
Bibtex Entry:
@article{Park2011,
abstract = {The Gene Ontology (GO) provides a controlled vocabulary for describing genes and gene products. In spite of the undoubted importance of GO, several drawbacks associated with GO and GO-based annotations have been introduced. We identified three types of semantic inconsistencies in GO-based annotations; semantically redundant, biological-domain inconsistent and taxonomy inconsistent annotations.},
author = {Park, Yu Rang and Kim, Jihun Ju Han and Lee, Hye Won and Yoon, Young Jo},
doi = {10.1186/1471-2105-12-S1-S40},
issn = {1471-2105},
journal = {BMC Bioinformatics},
keywords = {Computational Biology,Computational Biology: methods,Controlled,Database Management Systems,Databases,Genetic,Molecular Sequence Annotation,Proteins,Proteins: chemistry,Proteins: classification,SML-LIB-BIBLIO,Semantics,Software,Vocabulary,lang:ENG},
language = {en},
mendeley-tags = {SML-LIB-BIBLIO,lang:ENG},
month = jan,
number = {Suppl 1},
pages = {S40},
pmid = {21342572},
publisher = {BioMed Central Ltd},
title = {{GOChase-II: correcting semantic inconsistencies from Gene Ontology-based annotations for gene products.}},
url = {http://www.biomedcentral.com/1471-2105/12/S1/S40 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3044297\&tool=pmcentrez\&rendertype=abstract},
volume = {12 Suppl 1},
year = {2011}
}
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