Ontology-driven approaches to analyzing data in functional genomics

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by Francisco Azuaje, Fátima Al-Shahrour, Joaquín Dopazo
Abstract:
Ontologies are fundamental knowledge representations that provide not only standards for annotating and indexing biological information, but also the basis for implementing functional classification and interpretation models. This chapter discusses the application of gene ontology (GO) for predictive tasks in functional genomics. It focuses on the problem of analyzing functional patterns associated with gene products. This chapter is divided into two main parts. The first part overviews GO and its applications for the development of functional classification models. The second part presents two methods for the characterization of genomic information using GO. It discusses methods for measuring functional similarity of gene products, and a tool for supporting gene expression clustering analysis and validation.
Reference:
Ontology-driven approaches to analyzing data in functional genomics (Francisco Azuaje, Fátima Al-Shahrour, Joaquín Dopazo), In METHODS IN MOLECULAR BIOLOGY-CLIFTON THEN TOTOWA-, Springer, volume 316, 2005.
Bibtex Entry:
@article{Azuaje2005,
abstract = {Ontologies are fundamental knowledge representations that provide not only standards for annotating and indexing biological information, but also the basis for implementing functional classification and interpretation models. This chapter discusses the application of gene ontology (GO) for predictive tasks in functional genomics. It focuses on the problem of analyzing functional patterns associated with gene products. This chapter is divided into two main parts. The first part overviews GO and its applications for the development of functional classification models. The second part presents two methods for the characterization of genomic information using GO. It discusses methods for measuring functional similarity of gene products, and a tool for supporting gene expression clustering analysis and validation.},
author = {Azuaje, Francisco and Al-Shahrour, F\'{a}tima and Dopazo, Joaqu\'{\i}n},
journal = {METHODS IN MOLECULAR BIOLOGY-CLIFTON THEN TOTOWA-},
keywords = {SML-LIB-BIBLIO,clustering,expression data,functional genomics,gene ontology,lang:ENG,similarity},
mendeley-tags = {SML-LIB-BIBLIO,lang:ENG},
pages = {67},
publisher = {Springer},
title = {{Ontology-driven approaches to analyzing data in functional genomics}},
url = {http://www.springerlink.com/index/m8677327871272n3.pdf},
volume = {316},
year = {2005}
}
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