by Zhi-Ping Liu, Ling-Yun Wu, Yong Wang, Luonan Chen, Xiang-Sun Zhang
Abstract:
Annotation of protein functions is an important task in the post-genomic era. Most early approaches for this task exploit only the sequence or global structure information. However, protein surfaces are believed to be crucial to protein functions because they are the main interfaces to facilitate biological interactions. Recently, several databases related to structural surfaces, such as pockets and cavities, have been constructed with a comprehensive library of identified surface structures. For example, CASTp provides identification and measurements of surface accessible pockets as well as interior inaccessible cavities.
Reference:
Predicting gene ontology functions from protein's regional surface structures. (Zhi-Ping Liu, Ling-Yun Wu, Yong Wang, Luonan Chen, Xiang-Sun Zhang), In BMC Bioinformatics, volume 8, 2007.
Bibtex Entry:
@article{Liu2007a,
abstract = {Annotation of protein functions is an important task in the post-genomic era. Most early approaches for this task exploit only the sequence or global structure information. However, protein surfaces are believed to be crucial to protein functions because they are the main interfaces to facilitate biological interactions. Recently, several databases related to structural surfaces, such as pockets and cavities, have been constructed with a comprehensive library of identified surface structures. For example, CASTp provides identification and measurements of surface accessible pockets as well as interior inaccessible cavities.},
author = {Liu, Zhi-Ping and Wu, Ling-Yun and Wang, Yong and Chen, Luonan and Zhang, Xiang-Sun},
doi = {10.1186/1471-2105-8-475},
issn = {1471-2105},
journal = {BMC Bioinformatics},
keywords = {Binding Sites,Cluster Analysis,Computational Biology,Computational Biology: methods,Databases, Genetic,Models, Molecular,Pattern Recognition, Automated,Pattern Recognition, Automated: methods,Predictive Value of Tests,Protein Interaction Mapping,Protein Structure, Tertiary,Proteins,Proteins: chemistry,Proteins: metabolism,Proteomics,Proteomics: methods,SML-LIB-BIBLIO,Structural Homology, Protein,Structure-Activity Relationship,Vocabulary, Controlled,lang:ENG},
mendeley-tags = {SML-LIB-BIBLIO,lang:ENG},
month = jan,
pages = {475},
pmid = {18070366},
title = {{Predicting gene ontology functions from protein's regional surface structures.}},
url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2233648\&tool=pmcentrez\&rendertype=abstract},
volume = {8},
year = {2007}
}