by Seung Yon Rhee, Valerie Wood, Kara Dolinski, Sorin Draghici
Abstract:
The Gene Ontology (GO) project is a collaboration among model organism databases to describe gene products from all organisms using a consistent and computable language. GO produces sets of explicitly defined, structured vocabularies that describe biological processes, molecular functions and cellular components of gene products in both a computer- and human-readable manner. Here we describe key aspects of GO, which, when overlooked, can cause erroneous results, and address how these pitfalls can be avoided.
Reference:
Use and misuse of the gene ontology annotations. (Seung Yon Rhee, Valerie Wood, Kara Dolinski, Sorin Draghici), In Nature reviews. Genetics, volume 9, 2008.
Bibtex Entry:
@article{Rhee2008,
abstract = {The Gene Ontology (GO) project is a collaboration among model organism databases to describe gene products from all organisms using a consistent and computable language. GO produces sets of explicitly defined, structured vocabularies that describe biological processes, molecular functions and cellular components of gene products in both a computer- and human-readable manner. Here we describe key aspects of GO, which, when overlooked, can cause erroneous results, and address how these pitfalls can be avoided.},
author = {Rhee, Seung Yon and Wood, Valerie and Dolinski, Kara and Draghici, Sorin},
doi = {10.1038/nrg2363},
issn = {1471-0064},
journal = {Nature reviews. Genetics},
keywords = {Computational Biology,Databases,Genetic,Humans,Natural Language Processing,Proteins,Proteins: genetics,Proteins: metabolism,SML-LIB-BIBLIO,Software,lang:ENG},
mendeley-tags = {SML-LIB-BIBLIO,lang:ENG},
month = jul,
number = {7},
pages = {509--15},
pmid = {18475267},
title = {{Use and misuse of the gene ontology annotations.}},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18475267},
volume = {9},
year = {2008}
}